Level:PhD
Scholarship Description:
Bacterial pathogen subversion of the mammalian actin cytoskeleton
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Applications are invited for a PhD studentship, supervised by Prof. Vassilis Koronakis, to research mechanisms underlying bacterial pathogen subversion of the mammalian cytoskeleton.
Actin polymerisation is mediated by a complex signalling network requiring small G-protein activation that target N-WASP and the SCAR/WAVE complex to initiate Arp2/3-dependent actin nucleation.
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The detailed processes by which cellular signal transduction cascades lead to the formation of discrete actin structures remain unresolved. These signalling pathways are hijacked by pathogens like Salmonella and E.coli to promote colonisation, survival and dissemination, deploying virulence (effector) proteins to manipulate host actin dynamics.
The student will dissect key eukaryotic signalling networks targeted by these bacterial pathogens using a multidisciplinary approach involving the culture and infection of mammalian cells, cell biology, fluorescence microscopy, protein biochemistry and molecular genetics. Detailed characterisation of the mechanisms underlying actin polymerisation will not only reveal the molecular basis of disease, but also illuminate fundamental processes in cell biology.
Experience and/or Masters degree is desirable.All the applicants are supposed to have great interest in the area of research in the respective field.
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